6-Hydroxydopamine lesions in the medial prefrontal cortex of rats exposed to a peak-interval procedure
Psychol. neurosci. (Impr.)
; 7(2): 233-241, Jan.-June 2014. graf, tab
Article
in English
| Index Psychology - journals
| ID: psi-62657
Responsible library:
BR1.1
ABSTRACT
Impaired temporal control is symptomatic of several neurological disorders; recently, it has been implicated in schizophrenia. An animal model of schizophrenia using 6-hydroxydopamine (6-OHDA) infused to the medial pre-frontal cortex (mPFC) was employed to examine its effects on temporal control. Twelve rats were trained on a peak-interval procedure (PIP) until stable patterns of behavior were obtained. Rats infused with 6-OHDA responded less during peak trials and their peak functions were flatter than sham rats. These results are consistent with similar studies with transgenic mice with increased striatal dopamine D2 receptor activity. Lesions in the mPFC decreased motivation to respond in a PIP. These effects may be considered analogous to negative symptoms of schizophrenia.(AU)
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Collection:
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Brazil
Database:
Index Psychology - journals
Main subject:
Schizophrenia
/
Oxidopamine
/
Receptors, Dopamine D2
Limits:
Animals
Language:
English
Journal:
Psychol. neurosci. (Impr.)
Year:
2014
Document type:
Article
Institution/Affiliation country:
Armstrong Atlantic State University/United States