Effect of allopurinol on the kidney function, histology and injury biomarker (NGAL, IL 18) levels in uninephrectomised rats subjected to ischaemia-reperfusion injury
Acta cir. bras.
; 29(8): 515-521, 08/2014. tab, graf
Article
in En
| VETINDEX
| ID: vti-13044
Responsible library:
BR1.1
Localization: BR68.1
ABSTRACT
PURPOSE:
To investigate whether allopurinol exerts a protective effect on kidneys by measuring new kidney injury biomarkers (NGALp, NGALu, KIM 1 and IL 18) and analysing the renal function and histology in uninephrectomised rats subjected to ischaemia-reperfusion injury.METHODS:
Thirty two Wistar rats were randomly allocated to four groups Sham (S) laparotomy; Control (C) laparotomy and ischaemia-reperfusion in the left kidney; Control Allopurinol (CA) laparotomy and allopurinol at a dose of 100mg·kg 1·d 1; and Allopurinol (A) laparotomy ischaemia-reperfusion in the left kidney and allopurinol at a dose of 100mg·kg 1·d 1. The NGALp, NGALu, KIM 1, IL 18 and creatinine levels and the kidney histology were analysed. The significance level was established as p<0.05.RESULTS:
Creatinine level increased in all the groups, with A ≈ C > S ≈ CA. The NGALp, NGALu and IL 18 levels exhibited similar behaviour in all the groups. KIM 1 was higher in group A than C and showed intermediate values in groups S and CA. Severity of injury in the left kidney was greater in groups C and A compared to S and CA.CONCLUSION:
Allopurinol did not exert protective or damaging effects on the kidneys of rats subjected to ischaemia-reperfusion injury.(AU)Key words
Full text:
1
Database:
VETINDEX
Main subject:
Reperfusion Injury
/
Allopurinol
/
Acute Kidney Injury
Limits:
Animals
Language:
En
Journal:
Acta cir. bras.
Year:
2014
Document type:
Article
/
Project document