Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli
Braz. J. Microbiol.
; 46(3): 753-757, July-Sept. 2015. tab, ilus
Article
in En
| VETINDEX
| ID: vti-14828
Responsible library:
BR1.1
Localization: BR68.1
ABSTRACT
Quinolones and fluoroquinolones are widely used to treat uropathogenic Escherichia coli infections. Bacterial resistance to these antimicrobials primarily involves mutations in gyrA and parC genes. To date, no studies have examined the potential relationship between biochemical characteristics and quinolone resistance in uropathogenic E. coli strains. The present work analyzed the quinolone sensitivity and biochemical activities of fifty-eight lactose-negative uropathogenic E. coli strains. A high percentage of the isolates (48.3%) was found to be resistant to at least one of the tested quinolones, and DNA sequencing revealed quinolone resistant determining region gyrA and parC mutations in the multi-resistant isolates. Statistical analyses suggested that the lack of ornithine decarboxylase (ODC) activity is correlated with quinolone resistance. Despite the low number of isolates examined, this is the first study correlating these characteristics in lactose-negative E. coli isolates.(AU)
Key words
Full text:
1
Database:
VETINDEX
Main subject:
Ornithine Decarboxylase
/
Nalidixic Acid
/
Fluoroquinolones
/
Drug Resistance, Multiple, Bacterial
/
Escherichia coli Infections
/
Uropathogenic Escherichia coli
/
Lactose
Limits:
Humans
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Braz. J. Microbiol.
Year:
2015
Document type:
Article