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Safety and efficacy of a salmonella gallinarum cobScbiA strain with potential to prevent chicken infections by salmonella gallinarum and salmonella enteritidis
Paiva, JB; Penha Filho, RAC; Moura, BS; Berchieri Junior, A.
Affiliation
  • Paiva, JB; Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal Departamento de Patologia Veterinária.
  • Penha Filho, RAC; Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal Departamento de Patologia Veterinária.
  • Moura, BS; Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal Departamento de Patologia Veterinária.
  • Berchieri Junior, A; Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal Departamento de Patologia Veterinária.
Article in En | VETINDEX | ID: vti-717984
Responsible library: BR68.1
ABSTRACT
New vaccine design techniques have allowed the development of effective vaccine strains against Salmonella infections inwhich the risks of reversion to the wild type and virulence is null. The mutant strain Salmonella Gallinarum cobScbiA was previously shown to be avirulent in chickens. In this study, this strain was tested as a vaccine against Salmonella Gallinarum (SG) and S. Enteritidis (SE) infections, and its protection levels, safety and possible risks of reversion to virulence after vaccination of layers were evaluated. Birds were vaccinated at five days of age or at five and 25 days of age. At 45 days of age, brown and white layers were challenged with SG and SE wild strains, respectively. Two assays to test the possibility of reversion to virulence were performed. Five successive bacterial passages in brown layers were carried out in the first assay. In the second assay, brown layers received a ten-fold concentrated inoculum of the SGcobScbiA strain and were evaluated for clinical signs and mortality. In both experiments, no birds that received the inoculation of the attenuated strain died. Additionally, the use of the mutant strain as a vaccine provided good protection levels against both challenge strains.
Key words
Full text: 1 Database: VETINDEX Language: En Journal: R. bras. Ci. avíc. Year: 2012 Document type: Article
Full text: 1 Database: VETINDEX Language: En Journal: R. bras. Ci. avíc. Year: 2012 Document type: Article