Forma heterozigota da anomalia de Pelger-Huët em cão / A heterozygote form of Pelger-Huët anomaly in dog

ABSTRACT

Background: The Pelger-Huët anomaly is a congenital alteration in segmented neutrophil, eosinophil and basophil morphology consisting of nuclear hypo-segmentation. It presents in two ways the homozygote (very rare) presenting granulocytes with rounded nuclei and dense chromatin, where nuclei with more than two lobes are not found; and in the heterozygote form which presents leukocytes with bi-lobulated nuclei, yet leukocytes that seem immature can also be found. Diagnosis is important for preventing WBC interpretation errors. The objective of this study is to report a case of the heterozygote form of Perger-Huët anomaly in an Australian Shepherd bit.Case A 6-year-old Australian Shepherd bitch, weighing 28 kg, was received to perform tartar cleaning at the Veterinary Hospital (HV) of the Universidade Estadual de Maringá (UEM), in Umuarama in Paraná State. In the anamnesis, the owner reported that the animal was healthy, vaccinated, and had not made use of medications recently. Upon physical examination, the animal was overweight, with adequate hydration, alert consciousness level, no exo-parasites present, rectal temperature of 39.3°C (37.5 to 39.2), heart rate of 96 beats per min (60 to 120 beats per min), breathing (18 to 36 movements per min), a two second capillary perfusion time, strong and regular pulse, hyperemic oral mucosa, and otherwise, a normal-colored and popliteal reactive left lymph. Semiological evaluation presented no alteration. Due to the tartar cleaning procedure, a hemogram was requested. Blood smear analysis from the first blood workup showed a large increase in the number of hypo-segmented leukocytes, with a pattern of mature chromatin, in the form of bands and meta-myelocytes, characterizing a deviation to the left, all of which did not correspond to the patient’s clinical presentation.[...]