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The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
Azevedo, Vera Lucia Fernandes de; Santos, Paulo Sergio Santana; Oliveira Jr, Gildàsio Silveira de; Módolo, Gabriel Pinheiro; Domingues, Maria Aparecida Custódio; Castiglia, Yara Marcondes Machado; Vianna, Pedro Thadeu Galvão; Vane, Luiz Antonio; Módolo, Norma Sueli Pinheiro.
Affiliation
  • Azevedo, Vera Lucia Fernandes de; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. São Paulo. Brasil
  • Santos, Paulo Sergio Santana; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. São Paulo. Brasil
  • Oliveira Jr, Gildàsio Silveira de; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. São Paulo. Brasil
  • Módolo, Gabriel Pinheiro; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. São Paulo. Brasil
  • Domingues, Maria Aparecida Custódio; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. São Paulo. Brasil
  • Castiglia, Yara Marcondes Machado; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. São Paulo. Brasil
  • Vianna, Pedro Thadeu Galvão; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. São Paulo. Brasil
  • Vane, Luiz Antonio; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. São Paulo. Brasil
  • Módolo, Norma Sueli Pinheiro; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. São Paulo. Brasil
Acta cir. bras. ; 28(1): 5-9, 2013. ilus, tab
Article in En | VETINDEX | ID: vti-8931
Responsible library: BR1.1
Localization: BR68.1
ABSTRACT

PURPOSE:

To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia.

METHODS:

Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol.

RESULTS:

Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury.

CONCLUSION:

Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.(AU)
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Full text: 1 Database: VETINDEX Main subject: Acute Kidney Injury / Ischemia Limits: Animals Language: En Journal: Acta cir. bras. Year: 2013 Document type: Article / Project document
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Add to My VHL
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Full text: 1 Database: VETINDEX Main subject: Acute Kidney Injury / Ischemia Limits: Animals Language: En Journal: Acta cir. bras. Year: 2013 Document type: Article / Project document