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Sulfane sulfur deficiency in malignant cells, increasing the inhibiting action of acetone cyanohydrin in tumor growth
Ramalho, Rondon Tosta; Aydos, Ricardo Dutra; Schettert, Iandara; Assis, Peterson Vieira de; Cassino, Pedro Carvalho.
Affiliation
  • Ramalho, Rondon Tosta; Universidade Federal do Mato Grosso do Sul. Campo Grande. Brasil
  • Aydos, Ricardo Dutra; Universidade Federal do Mato Grosso do Sul. Departamento de Cirurgia. Campo Grande. Brasil
  • Schettert, Iandara; Universidade Federal do Mato Grosso do Sul. Departamento de Cirurgia. Campo Grande. Brasil
  • Assis, Peterson Vieira de; Universidade Federal do Mato Grosso do Sul. Campo Grande. Brasil
  • Cassino, Pedro Carvalho; Universidade Federal do Mato Grosso do Sul. Campo Grande. Brasil
Acta cir. bras. ; 28(10): 728-732, Oct. 2013. graf, tab
Article in En | VETINDEX | ID: vti-9056
Responsible library: BR1.1
Localization: BR68.1
ABSTRACT

PURPOSE:

To demonstrate the irreversible poisoning action of the acetone cyanohydrin (AC) in malignant cells.

METHODS:

Thirty male Swiss mice were inoculated with 1x10³ Ehrlich tumor (ET) cells. The mice were divided into three groups (n=10) CG (saline); ACG1 (1.864 mg/Kg of AC) and ACG2 (2.796 mg/Kg of AC), treated every 48 hours from day 3 until day 13. On day 15 the mice were euthanized and the number of viable cells in ascites was determined. In the meantime, ET cells were incubated with AC (0.5, 1.0, 2.0 μg/mL). Cell viability and percentage of growth inhibition (PGI) were checked after one, two, three, four, 18 and 24 hours.

RESULTS:

There was reduction in volume and number of viable cells in ACG1 and ACG2 compared to CG. In ACG1 one of the animals did not present ascites. In ACG2 two mice did not present ascites and in CG none of the mice present ascites. The action of AC was dose and time dependent and there was no significant difference among the three doses.

CONCLUSION:

The acetone cyanohydrin promoted reduction of the tumor and also prevented tumor development in 20% of the treated animals.(AU)
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Full text: 1 Database: VETINDEX Main subject: Acetone / Neoplasms Limits: Animals Language: En Journal: Acta cir. bras. Year: 2013 Document type: Article

Full text: 1 Database: VETINDEX Main subject: Acetone / Neoplasms Limits: Animals Language: En Journal: Acta cir. bras. Year: 2013 Document type: Article