Relation between hypercholesterolaemia and vascular endothelial microinflammation
(East. Mediterr. health j).
in English
| WHO IRIS
| ID: who-117278
Responsible library:
CH1.1
ABSTRACT
We investigated the correlation between hypercholesterolaemia and oxidative stress and P-selectin and interleukin-6 [IL-6] as markers for endothelial status. We studied 40 Egyptian adults with asymptomatic hypercholesterolaemia and 20 age- and sex-matched controls. Lipid peroxidation was significantly higher [P < 0.001] in the study group and positively correlated with cholesterol [P < 0.001] and low-density lipoprotein [LDL] [P < 0.002]. Glutathione peroxidase activity was also significantly higher [P < 0.001] with positive correlation with cholesterol [P < 0.001] and LDL [P < 0.001]. Markers for endothelial cell function were significantly higher in the study group [P < 0.001] with a positive correlation with cholesterol [P < 0.001] and LDL [P < 0.001]. Hypercholesterolaemia causes endothelial microinflammation, and P-selectin and IL-6 may also be risk factors for cardiovascular disease
Full text:
Available
Collection:
Databases of international organizations
Database:
WHO IRIS
Main subject:
Vascular Diseases
/
Endothelium, Vascular
/
Cholesterol
/
Hypercholesterolemia
Language:
English
Journal:
East. Mediterr. health j
Year:
2007