Assessment of the pharmaceutical quality of omeprazole capsule brands marketed in Egypt
(East. Mediterr. health j).
in English
| WHO IRIS
| ID: who-117393
Responsible library:
CH1.1
ABSTRACT
The pharmaceutical quality of 7 local omeprazole capsule brands in Egypt was assessed relative to the proprietary product [Losec[R]]. Drug content, content uniformity, drug release [using USP test for enteric coated articles and a modified release test] were determined. Products were subjected to a 3-month stability study. Of the 7 brands, 6 had satisfactory drug content and content uniformity. All brands passed the USP drug release test. The modified release test proved to be more discriminative. After 3 months storage, drug content of 3 brands remained > 90% and 2 of these brands maintained drug release above 75%. Changes in pellet appearance during storage were indicative of omeprazole chemical degradation
Full text:
Available
Collection:
Databases of international organizations
Database:
WHO IRIS
Main subject:
Tablets, Enteric-Coated
/
Omeprazole
/
Capsules
/
Chemistry, Pharmaceutical
/
Drug Costs
/
Drug Stability
/
Drug Storage
/
Anti-Ulcer Agents
Language:
English
Journal:
East. Mediterr. health j
Year:
2007