Nucleolus organizer region heteromorphism in patients with Down syndrome and their parents
(East. Mediterr. health j).
in English
| WHO IRIS
| ID: who-118708
Responsible library:
CH1.1
ABSTRACT
The study aimed to evaluate the role of nucleolus organizer region [NOR] heteromorphism as an etiological factor for parental nondisjunction in Down syndrome by comparing 25 patients affected by Down syndrome, and their parents with a control group of 80 non-affected Egyptians. All parents had normal karyotypes. The average modal number per parent of Ag-positive NORs was significantly higher in parents than controls. A significant difference in the size of the double-NOR variants [dNORs] was found. The mean maternal and paternal ages were significantly lower, with a significant increase in spontaneous abortions, for dNOR[+] couples compared with dNOR[-] couples
Full text:
Available
Collection:
Databases of international organizations
Database:
WHO IRIS
Main subject:
Pedigree
/
Nondisjunction, Genetic
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Infant, Newborn
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Pregnancy
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Case-Control Studies
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Abortion, Spontaneous
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Maternal Age
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Down Syndrome
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Karyotyping
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Nucleolus Organizer Region
Language:
English
Journal:
East. Mediterr. health j
Year:
1999