Bone marrow transplantation in thalassaemia patients in Shiraz, Islamic Republic of Iran
(East. Mediterr. health j).
in English
| WHO IRIS
| ID: who-119097
Responsible library:
CH1.1
ABSTRACT
We report the results of allogeneic bone marrow transplantation in 26 female and 37 male patients with beta-thalassaemia major [age range 2-17 years], performed at Namazi Hospital over the period 1992-99. In all cases, standard conditioning and immunosuppressive regimens were employed. Currently, 50 patients remain thalassaemia-free, 9 of whom have developed chronic graft-versus-host disease. There were 8 deaths among the 13 unsuccessful transplant cases 4 due to acute uncontrollable graft-versus-host disease, and 4 to non-transplant-related causes such as hypoglycaemia, hypersensitivity reactions and advanced disease. We conclude that allogeneic bone marrow transplantation is an effective therapy for the treatment of beta-thalassaemia major, particularly for patients classified as classes I and II
Full text:
Available
Collection:
Databases of international organizations
Database:
WHO IRIS
Main subject:
Prednisolone
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Child, Preschool
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Chronic Disease
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Bone Marrow Transplantation
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Immunoglobulins, Intravenous
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Beta-Thalassemia
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Transplantation Conditioning
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Graft Rejection
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Hypoglycemia
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Anti-Inflammatory Agents
Language:
English
Journal:
East. Mediterr. health j
Year:
2001