Characterization of invasive Neisseria meningitidis strains isolated at the Children's Hospital of Tunis, Tunisia
East. Mediterr. health j
; 22(5): 343-349, 2016-05.
Article
in English
| WHO IRIS
| ID: who-259971
Responsible library:
CH1.1
ABSTRACT
Neisseria meningitidis, a leading cause of bacterial meningitis and other serious infections, is responsible for approximately one-third of cases of bacterial meningitis in the Children's Hospital of Tunis. The serogroup distribution, antibiotic susceptibility and antigenic and molecular characteristics of N. meningitidis isolates were determined in patients aged 3 days-13 years between February 1998 and June 2013. In all 107 invasive strains of N. meningitidis were isolated. Reduced susceptibility to penicillin G was seen in 55.7% of isolates, with a low level of resistance in all cases; 28.4% showed a low level of resistance to amoxicillin. Serogroup B isolates were the most frequent [80.4%], followed by serogroups C [12.2%] and A [5.6%]. Isolates of serogroup A had the same antigenic formula [A4P1.9], the same variable regions VR1, VR2 and VR3, and belonged to the same clonal complex [CC5]. Isolates of serogroups B and C were more heterogeneous with several antigenic formulae. The most frequent clonal complex in these isolates was CC35. Serogroup B accounted for a large percentage of our isolates with marked diversity
Full text:
Available
Collection:
Databases of international organizations
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
/
SDG3 - Target 3.3 End transmission of communicable diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Neglected Diseases
/
Zoonoses
/
Meningitis
Database:
WHO IRIS
Main subject:
Penicillin G
/
Meningitis, Bacterial
/
Drug Resistance, Bacterial
/
Amoxicillin
/
Neisseria meningitidis
Language:
English
Journal:
East. Mediterr. health j
Year:
2016
Document type:
Article