Observational cohort study of the clinical outcomes associated with B.1.1.7/SGTF among hospitalized COVID-19 patients in Lebanon
East. Mediterr. health j
; 29(4): 262-270, 2023-04.
Article
in En
| WHOLIS
| ID: who-368519
Responsible library:
CH1.1
ABSTRACT
Background:
The B.1.1.7 SARS-CoV-2 variant results in spike gene target failure (SGTF) in reverse transcription-quantitative polymerase chain reaction (RT-PCR) assays. Few studies have been published on the clinical impact of B.1.1.7/SGTF.Aims:
To assess the incidence of B.1.1.7/SGTF and its associated clinical characteristics among hospitalized COVID-19 patients.Methods:
This observational, single-centre, cohort study was conducted between December 2020 and February 2021 and included 387 hospitalized COVID-19 patients. The Kaplan–Meier method was used for survival analysis, and logistic regression to identify risk factors associated with B.1.1.7/SGTF.Results:
By February 2021, B.1.1.7/SGTF (88%) dominated the SARS-CoV-2 PCR results in a Lebanese hospital. Of the 387 eligible COVID-19 patients confirmed by SARS-CoV-2 RT-PCR, 154 (40%) were non-SGTF and 233 (60%) were B.1.1.1.7/SGTF; this was associated with a higher mortality rate among female patients [22/51 (43%) vs 7/37 (19%); P = 0.0170]. Among patients in the B.1.1.7/SGTF group, most were aged ≥ 65 years [162/233 (70%) vs 74/154 (48%); P < 0.0001]. Independent predictors of B.1.1.7/SGTF infection were hypertension (OR = 0.415; CI 0.242–0.711; P = 0.0010), age ≥ 65 years (OR = 0.379; CI 0.231–0.622; P < 0.0001), smoking (OR = 1.698; CI 1.023–2.819; P = 0.0410), and cardiovascular disease (OR = 3.812; CI 2.215–6.389; P < 0.0001). Only non-SGTF patients experienced multi-organ failure [5/154 (4%) vs 0/233 (0%); P = 0.0096].Conclusion:
There was a clear difference between the clinical features associated with B.1.1.7/SGTF and non-SGTF lineages. Tracking viral evolution and its clinical impact is crucial for proper understanding and management of the COVID-19 pandemic.Key words
Full text:
1
Collection:
04-international_org
Database:
WHOLIS
Main subject:
Disease Outbreaks
/
Cohort Studies
/
Pandemics
/
Betacoronavirus
/
SARS-CoV-2
/
COVID-19
/
Lebanon
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Country/Region as subject:
Asia
Language:
En
Journal:
East. Mediterr. health j
Year:
2023
Document type:
Article