Factors Requiring Midazolam in Addition to Systemic Opioids to Control Dyspnea in Cancer Patients at the End of Life
Palliative Care Research
; : 247-252, 2023.
Article
in Japanese
| WPRIM (Western Pacific)
| ID: wpr-1007173
Responsible library:
WPRO
ABSTRACT
Background:
Factors requiring midazolam in addition to systemic opioids to control dyspnea in cancer patients have yet to be evaluated.Methods:
We retrospectively analyzed data for cancer patients who received systemic opioids to relieve dyspnea from April 2019 to July 2021 in Wakayama Medical University Hospital, Japan. Patients were divided into an opioid-alone group and an opioid plus midazolam group, according to the treatment of dyspnea.Results:
The total of 107 patients included 85 patients (79.4%) in the opioid alone group and 22 patients (20.6%) in the opioid plus midazolam group. Age<60 years (p=0.004) and male sex (p=0.034) was significantly associated with the addition of midazolam. Multivariate analysis found age <60 years (OR=5.34, 95%CI 1.66–17.21; p=0.005) was associated with the addition of midazolam.Conclusion:
Age <60 years is factor requiring midazolam in addition to systemic opioids to control dyspnea in cancer patients.
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Database:
WPRIM (Western Pacific)
Language:
Japanese
Journal:
Palliative Care Research
Year:
2023
Document type:
Article