Research advances in the role of Rab GTPases in Alzheimer's disease / 生理学报
Acta Physiologica Sinica
; (6): 817-835, 2023.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-1007793
Responsible library:
WPRO
ABSTRACT
Extracellular deposition of β-amyloid (Aβ) and intracellular hyperphosphorylated tau are the predominant pathological changes in Alzheimer's disease (AD). Increasing evidence demonstrates a critical role of a variety of small GTPases, namely Ras-related proteins (Rabs), in the pathogenesis of AD. As crucial regulators of intracellular membrane trafficking, alteration in Rab protein expression and function represents one of the primary factors contributing to the abnormal membrane trafficking in AD. Additionally, the Rab GTPases are also involved in the development of Aβ, tau and other pathological changes associated with AD. In this article, we conduct a comprehensive review on the primary functions of multiple Rab proteins and their involvement in the pathogenesis of AD.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Amyloid beta-Peptides
/
Tau Proteins
/
Rab GTP-Binding Proteins
/
Alzheimer Disease
Limits:
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2023
Document type:
Article