Two new sesquiterpenes in Qi-nan Aquilariae Lignum Resinatum / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 6403-6407, 2023.
Article
in Zh
| WPRIM
| ID: wpr-1008839
Responsible library:
WPRO
ABSTRACT
This study aimed to investigate the chemical constituents of supercritical extract from Qi-nan Aquilariae Lignum Resinatum by silica gel column chromatography, thin-layer chromatography, and semi-preparative high-performance liquid chromatography. One new elemane-type and one new eudesmane-type sesquiterpene compounds were isolated from the extract, and their structures were identified by MS, UV, IR, NMR, and ECD spectroscopic techniques, and named aquqinanol C(1) and aquqinanol D(2). Both compounds are novel compounds. The neuroprotective effect of the compounds on CORT-induced PC12 cell damage was determined in vitro. The results showed that compounds 1 and 2 exhibited a certain protective effect against CORT-induced damage in PC12 cells.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Sesquiterpenes
/
Molecular Structure
/
Qi
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2023
Document type:
Article