Alternative role of noncoding RNAs: coding and noncoding properties / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
; (12): 920-927, 2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-1010499
Responsible library:
WPRO
ABSTRACT
Noncoding RNAs (ncRNAs) have played a critical role in cellular biological functions. Recently, some peptides or proteins originating from annotated ncRNAs were identified in organism development and various diseases. Here, we briefly review several novel peptides translated by annotated ncRNAs and related key functions. In addition, we summarize the potential mechanism of bifunctional ncRNAs and propose a specific "switch" triggering the transformation from the noncoding to the coding state under certain stimuli or cellular stress. The coding properties of ncRNAs and their peptide products may provide a novel horizon in proteomic research and can be regarded as a potential therapeutic target for the treatment of various diseases.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Protein Biosynthesis
/
RNA, Messenger
/
Calcium
/
Open Reading Frames
/
RNA, Untranslated
Limits:
Animals
/
Humans
Language:
English
Journal:
Journal of Zhejiang University. Science. B
Year:
2019
Document type:
Article