Characteristics of chemotherapy-induced diabetes mellitus in acute lymphoblastic leukemia patients / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
; (12): 740-744, 2020.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-1010552
Responsible library:
WPRO
ABSTRACT
Acute lymphocytic leukemia (ALL) is one of the most common malignancies, especially in young people. Combination chemotherapy for ALL typically includes corticosteroids (Kantarjian et al., 2000). Hyperglycemia is a well-recognized complication of corticosteroids, and chemotherapy-induced diabetes (CID) is not uncommon (27.5%-37.0%) during the treatment of ALL (Hsu et al., 2002; Weiser et al., 2004; Alves et al., 2007). Besides the effect of corticosteroids, potential factors triggering hyperglycemia in ALL also include direct infiltration of the pancreas by leukemia cells and β cell dysfunction induced by chemotherapeutic agents such as L-asparagine (Mohn et al., 2004).
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Age Factors
/
Diabetes Mellitus
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Antineoplastic Agents
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Zhejiang University. Science. B
Year:
2020
Document type:
Article