Effect of menthol on hypobaric hypoxia-induced pulmonary arterial hypertension in mice and its mechanism

Wu-Shuai WANG; Ying-Rong HE; Xi YANG; Qing-Hua DUAN; Qiang WANG; Wu-Shuai WANG; Tao HU; Ying-Rong HE; Xi YANG; Qing-Hua DUAN; Xuan DU; Qiang WANG; Yao YANG; Xuan DU

Effect of menthol on hypobaric hypoxia-induced pulmonary arterial hypertension in mice and its mechanism / 中国药理学通报

Wu-Shuai WANG; Ying-Rong HE; Xi YANG; Qing-Hua DUAN; Qiang WANG; Wu-Shuai WANG; Tao HU; Ying-Rong HE; Xi YANG; Qing-Hua DUAN; Xuan DU; Qiang WANG; Yao YANG; Xuan DU.

Chinese Pharmacological Bulletin ; (12): 62-69, 2024.

Article in Chinese | WPRIM (Western Pacific) | ID: wpr-1013591

Responsible library: WPRO

ABSTRACT

ABSTRACT

Aim To study the effect of menthol on hypobaric hypoxia-induced pulmonary arterial hypertension and explore the underlying mechanism in mice. Methods 10 to 12 weeks old wild type (WT) mice and TRPM8 gene knockout (TRPM8

hypobaric hypoxia-induced pulmonary arterial hypertension; Kruppel-like factor 4; menthol; pulmonary artery smooth muscle cells (PASMCs); pulmonary vascular remodeling; transient receptor potential melastatin 8 (TRPM8)

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Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2024 Document type: Article

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Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2024 Document type: Article