Study on ameliorative effect of IDHP on excessive fat accumulation in hepatocytes

Jian DONG; Yu-Chuan ZHANG; Qiang SU; Na SUN; Jian DONG; Yu-Chuan ZHANG; Qiang SU; Ya-Jun BAI; Xiao-Hui ZHENG; Na SUN; Yan CHENG

Study on ameliorative effect of IDHP on excessive fat accumulation in hepatocytes / 中国药理学通报

Jian DONG; Yu-Chuan ZHANG; Qiang SU; Na SUN; Jian DONG; Yu-Chuan ZHANG; Qiang SU; Ya-Jun BAI; Xiao-Hui ZHENG; Na SUN; Yan CHENG.

Chinese Pharmacological Bulletin ; (12): 1541-1547, 2023.

Article in Chinese | WPRIM (Western Pacific) | ID: wpr-1013749

Responsible library: WPRO

ABSTRACT

ABSTRACT

Aim To explore whether isopropyl3-(3, 4-dihydroxyphenyl) -2-hydroxypropanoate (IDHP) could inhibit fat accumulation in liver cells by improving mitochondrial function, and alleviate the symptom of excessive fat accumulation in patients with NAFLD. Methods Cell steatosis model was established by inducing hepatocyte fat accumulation using palmitic acid and oleic acid (PA OA molar ratio =1

hepatocyte steatosis; IDHP; mitochondrial function; mitochondrial membrane potential; non-alcoholic fatty liver disease; PAOA

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Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2023 Document type: Article

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Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2023 Document type: Article