The protective effect of miR-5088-5p on hepatocyte pyroptosis induced by homocysteine

Xiao-Yan DONG; Da-Yue LIU; Ling-Bo XU; Yi-Deng JIANG; An-Ning YANG; Gui-Zhong LI; Xiao-Yan DONG; Da-Yue LIU; Ling-Bo XU; Ling-Yu GU; Yi-Deng JIANG; An-Ning YANG; Yun JIAO; Gui-Zhong LI; Xiao-Yan DONG; Da-Yue LIU; Ling-Bo XU; Ling-Yu GU; Yi-Deng JIANG; An-Ning YANG; Yun JIAO; Gui-Zhong LI; Ling-Yu GU; Yun JIAO

The protective effect of miR-5088-5p on hepatocyte pyroptosis induced by homocysteine / 中国药理学通报

Xiao-Yan DONG; Da-Yue LIU; Ling-Bo XU; Yi-Deng JIANG; An-Ning YANG; Gui-Zhong LI; Xiao-Yan DONG; Da-Yue LIU; Ling-Bo XU; Ling-Yu GU; Yi-Deng JIANG; An-Ning YANG; Yun JIAO; Gui-Zhong LI; Xiao-Yan DONG; Da-Yue LIU; Ling-Bo XU; Ling-Yu GU; Yi-Deng JIANG; An-Ning YANG; Yun JIAO; Gui-Zhong LI; Ling-Yu GU; Yun JIAO.

Chinese Pharmacological Bulletin ; (12): 1565-1570, 2021.

Article in Chinese | WPRIM (Western Pacific) | ID: wpr-1014265

Responsible library: WPRO

ABSTRACT

ABSTRACT

Aim To explore the role of miR-5088-5p in hepatocyte pyroptosis induced by homocysteine. Methods Hepatocytes were cultured and divided into control group and Hcy group. After transfected miR-5088-5p NC and miR-5088-5p mimic under Hcy treatment, the expression of NLRP3, Caspase 1 and IL-1β was detected by Western blot. The expression of miR-5088-5p was detected by RT-qPCR. CBS

CBS mice; hepatocyte; hyperhomocysteinemia; miRNA; miRNA-5088-5p; pyroptosis

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Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2021 Document type: Article

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Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2021 Document type: Article