Establishment of a limited sampling strategy to estimate micafungin exposure in critically ill patients / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
; (12): 1264-1271, 2022.
Article
in Zh
| WPRIM
| ID: wpr-1014758
Responsible library:
WPRO
ABSTRACT
AIM: To establish an ultra high performance liquid chromatography (UPLC) method for the determination of micafungin in plasma of critically ill patients. And to establish a model for estimating the area under the concentration-time curve (AUC) of micafungin by limited sampling strategy. METHODS: Patients with severe infection were administrated with micafungin once a day, 1 h for each infusion. The blood samples were collected before administration and 1, 2, 4, 8, 12, 24 h after administration and were measured by UPLC. The pharmacokinetic parameters were calculated by Phoenix winnonlin 6.4, and the drug concentrations at 2-4 blood collection points were analyzed with SPSS 22.0 to establish limited sampling models. RESULTS: The calibration curve was linear over a concentration range of 1.0 to 50 μg/mL (r
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Clinical Pharmacology and Therapeutics
Year:
2022
Document type:
Article