Correlation between changes of intestinal flora in children with Kawasaki disease and the levels of specific transcription factors RORγt, FOXP3 and T lymphocyte subsets / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
; (12): 154-160, 2021.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-1015079
Responsible library:
WPRO
ABSTRACT
AIM:
To explore the relationship between the changes of intestinal flora in children with Kawasaki disease (KD) and the specific transcription factor Rar related orphan receptor γt (RORγt), Fork head box P3 (FOXP3), and T lymphocyte subsets.METHODS:
A total of 110 children with KD in our hospital from January 2018 to June 2020 were selected and divided into simple KD group (68 cases) and KD co-infection group (42 cases) according to whether they were co-infected, and 42 healthy children during the same period were selected as the control group. The changes of the three groups of intestinal flora, RORγt, FOXP3, and T lymphocyte subsets were compared, and the relationship between the intestinal flora, RORγt, FOXP3, T lymphocyte subsets and KD co-infection was analyzed. Pearson correlation was used to analyze the correlation between the intestinal flora and RORγt, FOXP3, and T lymphocyte subsets.The receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC) were used to evaluate the predictive value of intestinal flora, RORγt, FOXP3, and T lymphocyte subsets for KD co-infection.RESULTS:
Lactobacillus, Veillonococcus, Clostridium, FOXP3, CD3
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Pharmacology and Therapeutics
Year:
2021
Document type:
Article