Advances in Study on Role of Neutrophil Infiltration in Helicobacter pylori Infection-related Diseases / 胃肠病学
Chinese Journal of Gastroenterology
; (12): 696-699, 2020.
Article
in Zh
| WPRIM
| ID: wpr-1016301
Responsible library:
WPRO
ABSTRACT
Helicobacter pylori (Hp) is a microaerophilic Gram-negative bacterium that colonizes the gastric mucosa. After colonization, many proteins expressed by Hp, such as Helicobacter pylori urease (HPU), neutrophil-activating protein (NAP), outer membrane protein (OMP), cytotoxin-associated gene A (CagA) and vacuolating cytotoxin A (VacA), may serve as antigens to mediate neutrophil chemotaxis. Thereafter, neutrophils infiltrate in gastric mucosa and play roles in mucosal immunity via secreting cytokines and releasing reactive oxygen species (ROS) and myeloperoxidase (MPO). This article reviewed the advances in study on the role of neutrophil infiltration in Hp infection-related diseases.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Gastroenterology
Year:
2020
Document type:
Article