Progress in Research on Influence of Autoantibodies on Biochemical Response and Prognosis in Patients With Primary Biliary Cholangitis / 胃肠病学
Chinese Journal of Gastroenterology
; (12): 445-448, 2020.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-1016357
Responsible library:
WPRO
ABSTRACT
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease, and may progress to cirrhosis and associated with complications of end-stage liver disease. The immunological characteristic of PBC is the presence of anti-mitochondrial autoantibodies (AMAs), and some anti-nuclear antibodies (ANAs) have high specificity for the diagnosis of PBC. In recent years, it has been found that anti-gp210, anti-sp100 and anti-centromere antibodies are correlated with the severity of PBC, treatment response to ursodeoxycholic acid (UDCA) and poor prognosis. However, correlation between AMAs and disease progression of PBC is still in controversial. This article reviewed the progress in research on the influence of autoantibodies on biochemical response and prognosis of PBC.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Gastroenterology
Year:
2020
Document type:
Article