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Research progress of ferroptosis and its mechanism of action on intestinal epithelial cells in inflammatory bowel disease / 中国药理学通报
Chinese Pharmacological Bulletin ; (12): 2210-2215, 2023.
Article in Zh | WPRIM | ID: wpr-1025712
Responsible library: WPRO
ABSTRACT
Inflammatory bowel disease(IBD)is a chronic pro-gressive inflammation of the gastrointestinal tract that damages the mucous membrane of the gastrointestinal tract.A growing number of studies have demonstrated that dysfunctional cell death occurs at inflammatory sites,leading to the destruction of the intestinal mechanical barrier and aggravation of inflammatory responses.Ferroptosis is a newly discovered form of programmed cell death mediated by iron-dependent lipid oxidation.There have been many articles that reported intestinal abnormal related factors of ferroptosis in patients with IBD.In view of the unclear current IBD specific pathogenesis and the many limitations in treatment,we summarize the research progress of ferroptosis mechanism in recent years,and expound the potential role of fer-roptosis in the pathogenesis of IBD,aiming to provide direction for the future study of the pathogenesis of IBD and the develop-ment and application of therapeutic drugs.
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Full text: 1 Database: WPRIM Language: Zh Journal: Chinese Pharmacological Bulletin Year: 2023 Document type: Article
Full text: 1 Database: WPRIM Language: Zh Journal: Chinese Pharmacological Bulletin Year: 2023 Document type: Article