The associations of SII and SIRI with the severity and prognosis of cervicocranial arterial dissection / 中风与神经疾病杂志

ABSTRACT

@#Objective To evaluate the relationship between the systemic immune-inflammation (SII) index,systemic inflammation response index (SIRI),and the severity and functional prognosis of patients with cervicocranial arterial dissection (CCAD). Methods A total of 101 patients with CCAD were enrolled and divided into the acute mild stroke group (n=48) and moderate to severe stroke group (n=15) caused by CCAD,and CCAD without stroke group (n=38). The SII index and SIRI were compared across the three groups. Logistic regression and receiver operating curve (ROC) analysis were performed to identify independent predictors of an unfavorable outcome and predictive power. Results Compared with CCAD without stroke group,patients with stroke had higher SII index and SIRI,and significantly higher values of these biomarkers were observed in patients with moderate/severe stroke than those with minor stroke (P<0.05). SII index and SIRI were associated with the NIHSS score at admission (rSII=0.306,PSII=0.002; rSIRI=0.271,PSIRI=0.006) and the mRS score at discharge (rSII=0.264,PSII=0.008; rSIRI=0.240,PSIRI =0.016). In multivariate analysis,elevated SII index,but not SIRI,was independently associated with poor short-term outcomes after CCAD (P<0.05). NIHSS score played a full mediation effect between SII index level and poor prognosis. The sensitivity of the SII index in predicting unfavorable clinical outcomes was 66.7%,the specificity was 82.6%,and the best critical value was 1 160.63×109/L. Conclusion Elevated SII index and SIRI values are associated with the severity and clinical outcomes of patients with CCAD. An elevated SII index,but not SIRI,could be an independent predicting factor for a poor short-term outcome after CCAD.