Gamma knife radiosurgery for intracranial chondrosarcoma:a report of 4 cases and literature review / 中华神经医学杂志

ABSTRACT

Objective To discuss the clinical effect of gamma knife radiosurgery on patients with intracranial chondrosarcoma.Methods Four patients with residual chondrosarcoma (one male and three female),admitted to our hospital from November 2004 to January 2012 and verified by biopsy,were chosen in our study; their clinical data were retrospectively analyzed; the mean age of patients was 31.3 years (ranged from 26-36 years).The mean tumor volume of these patients by gamma knife radiosurgery was 13.8 cm3 (ranged from 0.6-25.4 cm3).The mean dose delivered to the tumor margin was 17.3 Gy (ranged from 15-20 Gy) and the mean tumor maximum dose was 35 Gy (ranged from 30-40 Gy).A mean often isocenters (range 4-19) were used for dose planning.All patients were followed up for 5 to 28 months (mean 14.5 months).Results Two patients had residual chondrosarcoma located in the left mastoid,and jugular foramen area and saddle area were followed up for 19 and 9 months,respectively;their tumors did not increase and the patients were alive and enjoyed good living.Recurrence happened inone patient had the right residual orbit-cranial communicating chondrosarcoma at 28 months of follow-up; she accepted twice operations because of the recurrent tumors,but the outcome was bad; and she was dead at 56 months after gamma knife treatment.One patient had residual chondrosarcoma in the left parasella appeared tumor recurrence with hydrocephalus at 5 months of follow-up,and then,follow up was lost.All the four patients had no complications associated with gamma knife radiosurgery.Conclusion Gamma knife radiosurgery can be an auxiliary therapy for residual chondrosarcoma after craniotomy,enjoying advantages as high accuracy,reliable clinical efficacy,being less damage to the surrounding tissues.