Recent advance in role of ubiquitin-conjugating enzymes 2C in brain tumors / 中华神经医学杂志

ABSTRACT

Ubiquitin-conjugating enzymes 2C (UBE2C) is a pivotal component of the ubiquitin proteasome system and participates in the regulation of cell cycle. UBE2C is highly expressed in brain tumor tissues and the expression level of UBE2C is closely related to tumor malignancy and prognoses of these patients, therefore, UBE2C may become a biomarker for detection of brain tumors. We summarize the research progress of UBE2C in the occurrence, development, prognosis and molecular mechanism of brain tumors, in order to provide new points for the clinical prevention and treatment of brain tumors.