The influence of telmisartan in treatment of hypertrophy and the diastolic function of left ventricular in patients with hypertension / 中国现代医生

ABSTRACT

Objective To investigate the effects of telmisartan in treatment of hypertrophy and diastolic function of left ventricular in patients with hypertension and left ventricular. Methods A total of 78 patients admitted to our hospital with primary hypertension and myocardial hypertrophy and left ventricular diastolic dysfunction from April 2013 to May 2014 were selected as the research objects, and they were given telmisartan tablets orally, the differences of diastolic blood pressure (DBP), systolic blood pressure (SBP) changes and the ultrasonic heartbeat of each index recorded before and after treatment, recorded the heart function classification as well were compared. Results ①After the treatment, systolic and diastolic blood pressure were (107.6±9.9) mmHg and (73.3±5.2) mmHg, compared with the data of before treatment (153.5±12.6) mmHg and(98.9±8.0) mmHg, decreased significantly and there were statistical differences(P<0.05); ②After the treatment, left ventricular posterior wall thickness, index interventricular septum thickness, left ven-tricular end diastolic diameter, left ventricular mass index and late diastolic mitral flow velocity A were significantly lower than that before treatment (P<0.05); Early diastolic mitral flow velocity peak E increased significantly (P<0.05);③After treatment, the number of grade Ⅰ from 24 patients before treatment increased to 62 cases, cardiac function significantly improved after treatment(P<0.05). Conclusion The significant effect on primary hypertension and myocar-dial hypertrophy and left ventricular diastolic dysfunction by oral telmisartan, is worth the clinical promotion.