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Prognostic Significance of Ki-67 Expression in Rectal Carcinoid Tumors / 대한소화기학회지
Article in English | WPRIM (Western Pacific) | ID: wpr-103767
Responsible library: WPRO
ABSTRACT
BACKGROUND/

AIMS:

Rectal carcinoid tumors can be resected with endoscopy, and it is important to assess their prognostic factors. We evaluated the potential of Ki-67 expression as a prognostic factor in rectal carcinoid tumors.

METHODS:

We retrospectively reviewed the medical records of 37 patients with rectal carcinoid tumors who got endoscopic resection from January 2001 to January 2011 at Inje University Seoul Paik Hospital. We analyzed their endoscopic and histologic findings, Ki-67 expression, clinical outcome, and prognosis.

RESULTS:

The mean age (+/-SD) of the patients was 56.3+/-10.7 years, and the male female ratio was 3.61. The mean tumor size was 0.5+/-0.4 cm, 33 patients showed grade 1 tumors (89.2%) and the average Ki-67 expression was 0.7+/-1.2%. Thirty five patients underwent endoscopic mucosal resection, and two required endoscopic submucosal dissection. Eight patients had positive margins after resection, but no cases of lymphovascular invasion were identified. The median follow-up duration was 21.4+/-25.4 months, and no recurrences were observed.

CONCLUSIONS:

In low grade rectal carcinoid tumors which are lack of central depression on colonoscopy, the expression of a molecular marker of malignant potential, Ki-67, was low. Therefore, endoscopic resection seemed to be a safe and effective treatment for these tumors.
Subject(s)

Full text: Available Database: WPRIM (Western Pacific) Main subject: Prognosis / Rectal Neoplasms / Immunohistochemistry / Carcinoid Tumor / Sex Factors / Retrospective Studies / Colonoscopy / Age Factors / Ki-67 Antigen Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: The Korean Journal of Gastroenterology Year: 2013 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Prognosis / Rectal Neoplasms / Immunohistochemistry / Carcinoid Tumor / Sex Factors / Retrospective Studies / Colonoscopy / Age Factors / Ki-67 Antigen Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: The Korean Journal of Gastroenterology Year: 2013 Document type: Article
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