Epidemiology and Characteristics of Metallo-beta-Lactamase-Producing Pseudomonas aeruginosa / 감염과화학요법
Infection and Chemotherapy
; : 81-97, 2015.
Article
in En
| WPRIM
| ID: wpr-104521
Responsible library:
WPRO
ABSTRACT
Metallo-beta-lactamase-producing Pseudomonas aeruginosa (MPPA) is an important nosocomial pathogen that shows resistance to all beta-lactam antibiotics except monobactams. There are various types of metallo-beta-lactamases (MBLs) in carbapenem-resistant P. aeruginosa including Imipenemase (IMP), Verona integron-encoded metallo-beta-lactamase (VIM), Sao Paulo metallo-beta-lactamase (SPM), Germany imipenemase (GIM), New Delhi metallo-beta-lactamase (NDM), Florence imipenemase (FIM). Each MBL gene is located on specific genetic elements including integrons, transposons, plasmids, or on the chromosome, in which they carry genes encoding determinants of resistance to carbapenems and other antibiotics, conferring multidrug resistance to P. aeruginosa. In addition, these genetic elements are transferable to other Gram-negative species, increasing the antimicrobial resistance rate and complicating the treatment of infected patients. Therefore, it is essential to understand the epidemiology, resistance mechanism, and molecular characteristics of MPPA for infection control and prevention of a possible global health crisis. Here, we highlight the characteristics of MPPA.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Plasmids
/
Pseudomonas aeruginosa
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Monobactams
/
Carbapenems
/
Epidemiology
/
Infection Control
/
Drug Resistance, Multiple
/
Integrons
/
Germany
/
Anti-Bacterial Agents
Type of study:
Screening_studies
Limits:
Humans
Country/Region as subject:
Europa
Language:
En
Journal:
Infection and Chemotherapy
Year:
2015
Document type:
Article