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Effects of the C3G/D3G anthocyanins-rich black soybean testa extracts on improvement of lipid profiles in STZ-induced diabetic rats / 한국영양학회지
Article in Korean | WPRIM (Western Pacific) | ID: wpr-10568
Responsible library: WPRO
ABSTRACT

PURPOSE:

The purpose of this study was to examine the effect of black soybean (CJ-3) testa extracts on lipid profiles in streptozotocin (STZ)-induced diabetic rats.

METHODS:

One control group and four STZ-induced diabetic groups with different doses of black soybean (CJ-3) testa extracts treatment [0 mg/kg (diabetic control, EX), 250 mg/kg (EX-250), 500 mg/kg (EX-500), 1,000 mg/kg (EX-1000)] were orally administered for 4 weeks.

RESULTS:

All CJ-3 treatment groups had remarkably lower serum triglyceride (TG) levels than that of EX group (p < 0.05) whereas hepatic TG contents did not show any differences. Results from serum total cholesterol (TC) concentrations of EX-250 and EX-1000 groups were decreased compared to EX group (p < 0.05). Furthermore, protein levels of 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase from the liver decreased in all treatment groups (p < 0.05). However, significant differences were not observed in serum glucose and insulin, and glucose transporter 4 (GLUT-4) protein expression in skeletal muscle tissue.

CONCLUSION:

These results suggest that black soybean testa extracts could be useful for improvement of hyperlipidemia and hypercholesteremia in diabetes.
Subject(s)

Full text: Available Database: WPRIM (Western Pacific) Main subject: Oxidoreductases / Glycine max / Triglycerides / Blood Glucose / Cholesterol / Streptozocin / Muscle, Skeletal / Glucose Transport Proteins, Facilitative / Hypercholesterolemia / Hyperlipidemias Limits: Animals Language: Korean Journal: Journal of Nutrition and Health Year: 2015 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Oxidoreductases / Glycine max / Triglycerides / Blood Glucose / Cholesterol / Streptozocin / Muscle, Skeletal / Glucose Transport Proteins, Facilitative / Hypercholesterolemia / Hyperlipidemias Limits: Animals Language: Korean Journal: Journal of Nutrition and Health Year: 2015 Document type: Article
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