Effects of the C3G/D3G anthocyanins-rich black soybean testa extracts on improvement of lipid profiles in STZ-induced diabetic rats / 한국영양학회지
Journal of Nutrition and Health
; : 299-309, 2015.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-10568
Responsible library:
WPRO
ABSTRACT
PURPOSE:
The purpose of this study was to examine the effect of black soybean (CJ-3) testa extracts on lipid profiles in streptozotocin (STZ)-induced diabetic rats.METHODS:
One control group and four STZ-induced diabetic groups with different doses of black soybean (CJ-3) testa extracts treatment [0 mg/kg (diabetic control, EX), 250 mg/kg (EX-250), 500 mg/kg (EX-500), 1,000 mg/kg (EX-1000)] were orally administered for 4 weeks.RESULTS:
All CJ-3 treatment groups had remarkably lower serum triglyceride (TG) levels than that of EX group (p < 0.05) whereas hepatic TG contents did not show any differences. Results from serum total cholesterol (TC) concentrations of EX-250 and EX-1000 groups were decreased compared to EX group (p < 0.05). Furthermore, protein levels of 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase from the liver decreased in all treatment groups (p < 0.05). However, significant differences were not observed in serum glucose and insulin, and glucose transporter 4 (GLUT-4) protein expression in skeletal muscle tissue.CONCLUSION:
These results suggest that black soybean testa extracts could be useful for improvement of hyperlipidemia and hypercholesteremia in diabetes.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Oxidoreductases
/
Glycine max
/
Triglycerides
/
Blood Glucose
/
Cholesterol
/
Streptozocin
/
Muscle, Skeletal
/
Glucose Transport Proteins, Facilitative
/
Hypercholesterolemia
/
Hyperlipidemias
Limits:
Animals
Language:
Korean
Journal:
Journal of Nutrition and Health
Year:
2015
Document type:
Article