Efficacy of Long-Term Daily Dosage of Alfuzosin 10 mg upon Sexual Function of Benign Prostatic Hypertrophy Patients: Two-Year Prospective Observational Study
The World Journal of Men's Health
; : 133-138, 2014.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-106560
Responsible library:
WPRO
ABSTRACT
PURPOSE:
To identify sexual function improvement associated with alfuzosin (10 mg daily for 2 years). MATERIALS ANDMETHODS:
We enrolled 30 men with lower urinary tract symptom (LUTS) who visited Gyeongsang National University Hospital between 2010 and 2012. At first visit, urinalysis, prostate specific antigen, transrectal ultrasound, and uroflowmetry were performed. The nternational Prostate Symptom Score (IPSS), quality of life (QoL), International Index of Erectile Function (IIEF), and Male Sexual Health Questionnaire Ejaculation Function Domain (MSHQ-EjFD) questionnaires were administered, and the subjects answered the same questionnaires at 1 month, 6 months, 1 year, and 2 years of follow-up.RESULTS:
Twelve men completed of the entire study. After administration of alfuzosin, the median IPSS at first visit, 1 month, 6 months, 1 year, and 2 years was 18.00 (interquatile range [IQR] 14.00~29.75), 20.00 (IQR 11.50~30.00), 15.50 (IQR 8.50~25.25), 14.50 (IQR 9.25~19.50), and 11.50 (IQR 5.00~17.75), respectively, which showed an improvement. The median QoL at the same times was 4.50 (IQR 4.00~5.00), 4.50 (IQR 4.00~5.00), 3.00 (IQR 2.00~4.00), 3.50 (IQR 2.25~4.00), and 3.00 (IQR 1.00~3.00), respectively, and also showed improvement. Likewise, the median IIEF was 36.50 (IQR 24.50~46.75), 37.50 (IQR 26.75~47.25), 45.50 (IQR 35.00~59.75), 48.50 (IQR 34.75~62.75), and 47.50 (IQR 43.25~61.00), while the median MSHQ-EjFD was 19.00 (IQR 12.0~24.75), 19.50 (IQR 13.50~27.75), 23.00 (IQR 19.25~32.25), 26.50 (IQR 18.25~34.50), 27.00 (IQR 21.50~32.50), respectively, with both showing improvement.CONCLUSIONS:
After administration of alfuzosin (10 mg daily for 2 years), the IPSS, QoL, IIEF, and MSHQ-EjFD all improved significantly. This means long-term administration of 10 mg of alfuzosin daily would be effective not only for LUTS but also erectile function and ejaculation.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatic Hyperplasia
/
Quality of Life
/
Urinary Tract
/
Penile Erection
/
Prospective Studies
/
Surveys and Questionnaires
/
Follow-Up Studies
/
Ultrasonography
/
Urinalysis
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Aspects:
Patient-preference
Limits:
Humans
/
Male
Language:
English
Journal:
The World Journal of Men's Health
Year:
2014
Document type:
Article