Delayed presentation of aggravation of thyrotoxicosis after radioactive iodine therapy at Graves disease / 영남의대학술지
Yeungnam University Journal of Medicine
; : 148-151, 2014.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-106563
Responsible library:
WPRO
ABSTRACT
Radioactive iodine (RAI) therapy is widely used for the treatment of Graves disease. After RAI therapy, 44% become hypothyroid and up to 28% remain hyperthyroid. The development of thyrotoxicosis after RAI therapy is believed to be mediated by 2 different mechanisms a transient increased release of thyroid hormone due to radiation thyroiditis and the rare development of Graves disease due to the formation of antibodies to the thyroid-associated antigens released from the damaged follicular cells. A 55-year-old woman was hospitalized with severe headache, weight loss, and palpitation. She received a dose of 7 mCi of RAI (I-131) about 6 weeks earlier. Thyroid function test showed 7.98 ng/dL free T4, >8 ng/mL T3, <0.08 microIU/L thyroid stimulating hormone, and high titer thyroid stimulating immunoglobulin (TSI) (85.8 IU/L). She improved with propylthiouracil, propranolol, and steroid treatment. The TSI, however, was persistently elevated for 11 months.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Propranolol
/
Propylthiouracil
/
Thyroid Function Tests
/
Thyroid Gland
/
Thyroiditis
/
Thyrotoxicosis
/
Thyrotropin
/
Weight Loss
/
Graves Disease
/
Immunoglobulins, Thyroid-Stimulating
Limits:
Female
/
Humans
Language:
Korean
Journal:
Yeungnam University Journal of Medicine
Year:
2014
Document type:
Article