Chromosomal Abnormalities in Myelodysplastic Syndrome with Near-tetraploidy: A Case Report
Laboratory Medicine Online
; : 47-50, 2012.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-106976
Responsible library:
WPRO
ABSTRACT
Massive hyperdiploidy and tetraploidy are rare cytogenetic abnormalities in myelocytic malignancies, especially in myelodysplastic syndrome (MDS). These abnormalities are known to be associated with leukemogenesis, leukemic transformation and poor prognosis. We report here the first case of MDS with near-tetraploid cytogenetic abnormality in Korea. A 80-yr-old male was diagnosed with refractory anemia with excess blasts-2 (RAEB-2). Bone marrow aspiration smear showed 16% of blasts, which were large sized myeloid blasts with irregular margins and cytoplasmic vacuolation. Cytogenetic analysis of bone marrow cells revealed numercal and structural cytogenetic abnormalities including near-tetraploidy in 8 of 20 metaphases 45,XY,add(1)(p36.1),del(10)(p11.2),del(11)(q13),-12,-16,der(17)t(11;17) (q13;q21),add(20)(q13.1),+mar[8]/85~90,idemx2[cp8]/46,XY[4]. After chemotherapy with decitabine, he showed pancytopenia during follow-up period and died of sepsis 14 months after the diagnosis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pancytopenia
/
Prognosis
/
Azacitidine
/
Bone Marrow
/
Myelodysplastic Syndromes
/
Anemia, Refractory
/
Bone Marrow Cells
/
Follow-Up Studies
/
Chromosome Aberrations
/
Sepsis
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
Korean
Journal:
Laboratory Medicine Online
Year:
2012
Document type:
Article