Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
Clinical Psychopharmacology and Neuroscience
; : 250-255, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-108199
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis.METHODS:
We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (−759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system.RESULTS:
We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group.CONCLUSION:
This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Serotonin
/
Risk Factors
/
Promoter Regions, Genetic
/
Headache Disorders
/
Polymorphism, Single Nucleotide
/
Receptor, Serotonin, 5-HT2C
/
Alleles
/
Genetic Association Studies
/
Healthy Volunteers
/
Headache
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2016
Document type:
Article