The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes
The Korean Journal of Internal Medicine
; : 620-629, 2014.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-108339
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
Recent epidemiological studies revealed a striking inverse relationship between vitamin D levels, glucose intolerance/insulin resistance (IR), and cardiovascular disease. However, few interventional studies have evaluated the effect of vitamin D supplementation on cardiovascular risk, such as IR and arterial stiffness, in diabetes. We investigated the role of vitamin D supplementation on cardiovascular risk in type 2 diabetes patients, including metabolic parameters, IR, and arterial stiffness.METHODS:
We enrolled patients who were taking antidiabetic medications or managed their diabetes using lifestyle changes. We excluded patients who were taking vitamin D or calcium supplements. We randomized participants into the vitamin D group (cholecalciferol 2,000 IU/day + calcium 200 mg/day, n = 40) or the placebo group (calcium 200 mg/day, n = 41). We compared their IR (homeostasis model of assessment [HOMA]-IR) and arterial stiffness (brachial-ankle pulse wave velocity and radial augmentation index) before and after 24 weeks of intervention.RESULTS:
The baseline characteristics of the two groups were similar. A total of 62 participants (placebo, 30; vitamin D, 32) completed the study protocol. At the end of the study period, the 25-hydroxyvitamin D [25(OH)D] levels were significantly higher in the vitamin D group than in the placebo group (35.4 +/- 8.5 ng/mL vs. 18.4 +/- 7.3 ng/mL, p < 0.001). There was no difference in HOMA-IR or changes in arterial stiffness (placebo, 21, vitamin D, 24) between the groups.CONCLUSIONS:
Our data suggest that high-dose vitamin D supplementation might be effective in terms of elevating 25(OH)D levels. However, we identified no beneficial effects on cardiovascular risk in type 2 diabetes, including IR and arterial stiffness.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Vitamin D
/
Vitamin D Deficiency
/
Insulin Resistance
/
Calcium, Dietary
/
Double-Blind Method
/
Prospective Studies
/
Cholecalciferol
/
Diabetes Mellitus, Type 2
/
Vascular Stiffness
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2014
Document type:
Article