A Clinical Study of Sepsis with Thrombocytopenia in Premature Infants / 소아과
Korean Journal of Pediatrics
; : 1058-1064, 2004.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-108575
Responsible library:
WPRO
ABSTRACT
PURPOSE:
This study was performed to characterize sepsis with thrombocytopenia in premature infants to determine if thrombocytopenia is a prognostic factor in sepsis in premature infants.METHODS:
We retrospectively analyzed the medical records of sepsis in premature infants admitted to the neonatal intensive care unit(N=41) at the Hallym University Sacred Heart Hospital from January 1999 to December 2002. The incidence, risk factors, symptoms, hematologic and bacteriologic findings were analyzed during episodes of sepsis.RESULTS:
Of the 41 cases, 29(72%) were associated with thrombocytopenia. The ratio of male to female was 1.2 1. The vast majority(98%) were late-onset sepsis. The risk factors of the thrombocytopenic group were low birth weight and low gestational age. Major symptoms were poor activity (72%), apnea/tachypnea(52%), but were not significantly different between two groups. In the thrombocytopenic group(N=29), low total WBC count and high CRP level were discovered(P=0.03, P<0.01). The mean platelet count was 70.17(x103/mm3) at diagnosis of sepsis, and a mean platelet nadir was 43.10(x103/mm3). The severe thrombocytopenia(below 50x103/mm3) in the thrombocytopenic group was discovered in 69% and the duration of thrombocytopenia was about eight days. The majority of pathogens were gram-negative bacteria and candida. The thrombocytopenic group showed a pro longed length of stay and a high mortality rate. According to comparisons between the survived and expired groups, low birth weight, low gestational age, neutropenia and thrombocytopenia were significantly correlated with mortality(P<0.05).CONCLUSION:
The sepsis with thrombocytopenia in premature infants showed late-onset sepsis and high morbidity and mortality, although differences were not significant statistically. Especially, low birth weight and low gestational aged infants should be cautiously treated and monitored.
Full text:
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Health context:
SDG3 - Health and Well-Being
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SDG3 - Target 3.3 End transmission of communicable diseases
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SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
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SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Target 3.2: Reduce avoidable death in newborns and children under 5
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Sepsis
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Other Blood Disorders
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Infections
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Neonatal Healthcare
Database:
WPRIM (Western Pacific)
Main subject:
Platelet Count
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Thrombocytopenia
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Blood Platelets
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Candida
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Infant, Low Birth Weight
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Infant, Premature
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Intensive Care, Neonatal
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Medical Records
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Incidence
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Retrospective Studies
Type of study:
Diagnostic study
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Etiology study
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Incidence study
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Observational study
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Prognostic study
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Risk factors
Limits:
Female
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Humans
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Infant
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Male
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Infant, Newborn
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2004
Document type:
Article