Altered Cell Viability and Proliferation Activity of Peripheral Lymphocytes in Patients with Alzheimer's Disease
Psychiatry Investigation
; : 68-71, 2010.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-109335
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
We evaluated cell viability and proliferation activity of peripheral lymphocytes as potential models of neuronal death in Alzheimer's disease (AD).METHODS:
We analyzed the cell viability and proliferation activity of phytohemagglutinin (PHA)-activated lymphocytes from 68 AD patients and 33 normal controls. The cellular measures were made at baseline (0 hr), 24 hrs, 48 hrs, 72 hrs, and 96 hrs after PHA stimulation.RESULTS:
Cell viability in the AD patients was significantly decreased at 72 hrs and 96 hrs, compared with the normal controls. The declining ramp of the proliferation activity from 48 hrs to 72 hrs after PHA stimulation was significantly related to cell viability at 72 hrs and at 96 hrs in the AD patients.CONCLUSION:
Lymphocytes from patients with AD have altered viability and proliferation characteristics in culture following PHA stimulation. These findings suggest that lymphocytes may be used as a peripheral tissue model of cell cycle dysregulation in AD.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Alzheimer’s Disease and other Dementias
/
Mental Health and Behavioral Disorders
Database:
WPRIM (Western Pacific)
Main subject:
Architectural Accessibility
/
Lymphocytes
/
Cell Cycle
/
Cell Survival
/
Cell Death
/
Alzheimer Disease
/
Neurons
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2010
Document type:
Article