The efficacy of nuchal translucency with free beta-hCG, PAPP-A as a screening test for detection of chromosomal anomaly in the first trimester of pregnancy / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 1091-1096, 2001.
Article
in Ko
| WPRIM
| ID: wpr-110125
Responsible library:
WPRO
ABSTRACT
OBJECTIVES: The aim of this study is to determine the efficacy of nuchal translucency in combination with free beta-hCG, PAPP-A in the first trimester screening for chromosomal anomaly in general population. METHODS: Between April 1998 and December 1999, we evaluated 263 pregnant women undergoing first trimester screening test for fetal chromosomal anomaly using nuchal translucency combined with free beta-hCG, PAPP-A. We confirmed the pregnancy outcomes through chorionic villi sampling, amniocentesis or term delivery. We excluded 15 pregnant women because of their obscure pregnancy outcomes. Statistical analysis was considered significant when P value was lower than 0.05. RESULTS: With a risk cut-off of 1 in 400, 24 pregnancies(9.7%) of 248 cases were screen positive and 224 pregnancies(90.3%) were screen negative. 2 cases of Down syndrome and 1 case of Turner syndrome were detected in screen positive group. No chromosomal anomalies were detected in screen negative group. CONCLUSION: In this study, 8.57% of false positive rate and 12.5% of positive predictive value were obtained in the first trimester screening for chromosomal anomaly using nuchal translucency and serum markers.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Pregnancy-Associated Plasma Protein-A
/
Pregnancy Trimester, First
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Turner Syndrome
/
Pregnancy Outcome
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Biomarkers
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Chorionic Villi Sampling
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Mass Screening
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Down Syndrome
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Pregnant Women
/
Nuchal Translucency Measurement
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Female
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Humans
/
Pregnancy
Language:
Ko
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2001
Document type:
Article