The Combined Impact of Neutrophil-to-Lymphocyte Ratio and Type 2 Diabetic Mellitus on Significant Coronary Artery Disease and Carotid Artery Atherosclerosis
Journal of Cardiovascular Ultrasound
; : 115-122, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-11231
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Neutrophil-to-lymphocyte ratio (NLR) has recently emerged as a new important inflammatory marker for predicting cardiovascular events. This study aimed to evaluate the combined impact of NLR and type 2 diabetes mellitus (T2DM) on significant coronary artery disease (CAD) and carotid artery atherosclerosis.METHODS:
This study includes a total of 828 patients evaluated by coronary angiography and carotid ultrasonography. Significant CAD was defined as at least one vessel with stenosis greater than 50%. We employed logistic regression models to investigate the association of NLR and T2DM with significant CAD. The goodness-of-fit and discriminability of the models were assessed by the loglikelihood ratio test and C-index, respectively. Also, we investigated the clinical relevance of the categorized NLR that classifies patients into three risk groups (low, intermediate, high).RESULTS:
According to logistic regression analysis, both NLR {adjusted odds ratio (OR) 1.31, p 2) showed the greater prevalence of significant CAD and carotid artery atherosclerosis compared with patients without T2DM or type 2 diabetic patients assigned into the low risk group (NLR ≤ 1).CONCLUSION:
Our results suggest that type 2 diabetic patients with high inflammatory state would be more vulnerable to significant CAD and carotid artery atherosclerosis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Coronary Artery Disease
/
Carotid Arteries
/
Logistic Models
/
Odds Ratio
/
Prevalence
/
Risk Factors
/
Ultrasonography
/
Coronary Angiography
/
Constriction, Pathologic
/
Coronary Vessels
Type of study:
Diagnostic study
/
Etiology study
/
Prevalence study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of Cardiovascular Ultrasound
Year:
2016
Document type:
Article