Novel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: a proof-of-concept study
Journal of Periodontal & Implant Science
; : 136-143, 2012.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-11333
Responsible library:
WPRO
ABSTRACT
PURPOSE:
The osseointegration around titanium mini-implants installed in macroporous biphasic calcium phosphate (MBCP) blocks was evaluated after incubation with recombinant human bone morphogenetic protein-2 (rhBMP-2) in an ectopic subcutaneous rat model.METHODS:
Mini-implants (phi1.8x12 mm) were installed in MBCP blocks (bMBCPs, 4x5x15 mm) loaded with rhBMP-2 at 0.1 mg/mL, and then implanted for 8 weeks into subcutaneous pockets of male Sprague-Dawley rats (n=10). A histomorphometric analysis was performed, and the bone-to-implant contact (BIC) and bone density were evaluated.RESULTS:
Significant osteoinductive activity was induced in the rhBMP-2/bMBCP group. The percentage of BIC was 41.23+/-4.13% (mean+/-standard deviation), while bone density was 33.47+/-5.73%. In contrast, no bone formation was observed in the bMBCP only group.CONCLUSIONS:
This model represents a more standardized tool for analyzing osseointegration and bone healing along the implant surface and in bMBCPs that excludes various healing factors derived from selected animals and defect models.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Titanium
/
Recombinant Proteins
/
Bone Density
/
Dental Implants
/
Calcium
/
Osseointegration
/
Transforming Growth Factor beta
/
Rats, Sprague-Dawley
/
Bone Morphogenetic Protein 2
Type of study:
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Journal of Periodontal & Implant Science
Year:
2012
Document type:
Article