Prevalence and Treatment Efficacy of Genitourinary Mycoplasmas in Women with Overactive Bladder Symptoms
Korean Journal of Urology
; : 625-630, 2010.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-113367
Responsible library:
WPRO
ABSTRACT
PURPOSE:
To evaluate the incidence of genitourinary mycoplasmas and the efficacy of antibiotics in women with overactive bladder (OAB) symptoms. MATERIALS ANDMETHODS:
Women with OAB symptoms (micturition > or =8/24 hours and urgency > or =1/24 hours) for > or =3 months were screened for Mycoplasma hominis (M. hominis), Ureaplasma urealyticum (U. urealyticum), and Chlamydia trachomatis (C. trachomatis). Specimens from urethral and cervical vaginal swabs were examined for M. hominis and U. urealyticum by using the Mycoplasma IST2 kit and for C. trachomatis by using PCR. Women with positive results were treated with a 1 g dose of azithromycin. Persistent infection was treated with doxycycline. Changes in a 3-day bladder diary, Patient Perception of Bladder Condition (PPBC), and International Consultation on Incontinence Questionnaire-Female Lower Urinary Tract Symptoms (ICIQ-FLUTS) were evaluated 4 weeks after negative conversion. Patient satisfaction was assessed.RESULTS:
Of 84 women screened, 42.8% were positive (U. urealyticum, 40.5%; M. hominis, 7.1%; C. trachomatis, 3.6%; two organisms, 8.3%). After treatment, 82.7% obtained negative conversion, and their median number of micturition episodes decreased from 10.6/24 hours to 8.1/24 hours (p=0.002). PPBC and domain scores of the ICIQ-FLUTS (filling and quality of life) significantly improved. About 87.5% women with negative conversion were satisfied with the treatment.CONCLUSIONS:
Considering diagnostic tests and treatment for genitourinary mycoplasmas might be beneficial before invasive workup or treatment in women with OAB symptoms.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Urination
/
Urinary Bladder
/
Chlamydia trachomatis
/
Polymerase Chain Reaction
/
Incidence
/
Prevalence
/
Ureaplasma urealyticum
/
Treatment Outcome
/
Patient Satisfaction
/
Doxycycline
Type of study:
Diagnostic study
/
Incidence study
/
Prevalence study
/
Prognostic study
Aspects:
Patient-preference
Limits:
Female
/
Humans
Language:
English
Journal:
Korean Journal of Urology
Year:
2010
Document type:
Article