Impaired homeostatic mechanism of potassium handling after acute oral potassium load in diabetes mellitus
Journal of Korean Medical Science
; : 10-16, 1993.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-118160
Responsible library:
WPRO
ABSTRACT
Chronic stable diabetic patients (n = 6) were compared with healthy control subjects (n = 5) after acute oral intake of 50 mEq of potassium chloride (KCl) to investigate for possible derangements of homeostatic responses for acute term (3 hrs) to acute potassium load. Plasma renin activity (PRA), plasma aldosterone (PA), and transtubular potassium concentration gradient (TTKG) known as a useful semiquantative index of distal nephron potassium secretion were measured. All the baseline parameters were comparable between diabetic and non-diabetic subjects except for significantly reduced creatinine clearance in diabetics (mean +/- SEM, 105 +/- 4 vs. 85 +/- 5 ml/min, p 5.0 mEq/L). PRA did not show any significant changes, whereas PA was increased simultaneously with increments in serum potassium in both groups, with blunted increases in the diabetics. However, TTKG was increased prominently in control subjects (8.18 from 4.98), but only slightly in diabetic subjects (4.55 from 4.18), with statistical difference between the two groups (p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Potassium
/
Renin
/
Diabetes Mellitus, Type 2
/
Aldosterone
/
Homeostasis
/
Kidney Tubules
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
1993
Document type:
Article