Neuroprotective Effect of Lacosamide on Hypoxic-Ischemic Brain Injury in Neonatal Rats
Journal of Clinical Neurology
; : 138-143, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-119362
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE:
Lacosamide (LCM) is an antiepileptic drug that enhances the slow inactivation of sodium channels and modulates collapsin response mediator protein-2. LCM was recently demonstrated to exert a neuroprotective effect in a murine model of traumatic brain injury and status epilepticus. Assuming the same underlying excitotoxicity-related brain injury mechanism, we hypothesized that LCM would have a neuroprotective effect in hypoxic-ischemic brain injury.METHODS:
We divided rats into three groups at each testing session pre- or postfed with LCM, fed with normal saline, and sham. A hypoxic-ischemic brain injury was induced by subjecting 7-day-old rats to right carotid artery coagulation followed by 2.5 h of exposure to 8% oxygen. The animals were killed on postnatal day 12 to evaluate the severity of brain damage. Open field testing was also performed between week 2 and week 6, and the Morris water maze test was performed in week 7 after hypoxia-ischemia.RESULTS:
The incidence of liquefactive cerebral infarction was lower in rats prefed with LCM at 100 mg/kg/dose, with the mortality rate being higher at higher doses (200 and 300 mg/kg/dose). The infarct areas were smaller in LCM-prefed rats in several brain regions including the hemisphere, hippocampus, cortex, and striatum. Spatial learning and memory function were better in LCM-prefed rats (p<0.05). No effect was observed in postfed rats.CONCLUSIONS:
This study suggests that LCM pretreatment exerts a neuroprotective effect on hypoxia-ischemia in neonatal rats. The obtained results suggest that LCM pretreatment could be used as an effective neuroprotective method for neonates under hypoxic-ischemic conditions including heart surgery.
Full text:
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Health context:
SDG3 - Health and Well-Being
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SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
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SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Target 3.2: Reduce avoidable death in newborns and children under 5
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Cardiovascular Disease
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Cerebrovascular Disease
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Epilepsy
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Neonatal Healthcare
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Noncommunicable Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Oxygen
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Status Epilepticus
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Thoracic Surgery
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Brain
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Brain Injuries
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Water
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Carotid Arteries
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Sodium Channels
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Cerebral Infarction
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Incidence
Type of study:
Incidence study
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Prognostic study
Limits:
Animals
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Humans
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2017
Document type:
Article