Adiposity in the Relationship between Serum Vitamin D Level and Insulin Resistance in Middle-Aged and Elderly Korean Adults: The Korea National Health and Nutrition Examination Survey 2008
Endocrinology and Metabolism
; : 96-102, 2013.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-119445
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
The role of adiposity in the relationship between serum vitamin D levels and insulin resistance has not yet been fully studied. This aim of this study is to clarify the role of adiposity in the relationship between serum vitamin D level and insulin resistance among middle-aged and elderly Korean adults.METHODS:
We used data from 2,710 individuals aged > or =50 years based on national data from a representative sample of the fourth Korea National Health and Nutrition Examination Survey IV-2 in 2008.RESULTS:
After adjustment for potential confounders, body mass index (BMI) was significantly associated with 25(OH) vitamin D (P=0.008). However, waist circumference was not significantly associated with 25(OH) vitamin D. In the stratified analyses, 25(OH) vitamin D was found to be negatively associated with fasting insulin and homeostasis model assessment estimate of insulin resistance (HOMA-IR) in participants with BMIs > or =25 kg/m2 (P=0.003 for both insulin and HOMR-IR) but was not found to be associated in those with BMIs <23 kg/m2. However, we observed a significant inverse in the association of 25(OH) vitamin D with fasting insulin and HOMA-IR in both the normal (P=0.001 and P<0.001 and the abdominally obese group (P=0.010 and P=0.009) in the stratified analyses according to abdominal obesity.CONCLUSION:
Our results support that the idea that endogenously-produced vitamin D might be stored in subcutaneous fat deposits. In addition, the association of vitamin D with insulin resistance in middle-aged and elderly Korean adults was stronger when it was stratified by BMI than when abdominal obesity status.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Vitamin D
/
Vitamins
/
Insulin Resistance
/
Body Mass Index
/
Nutrition Surveys
/
Fasting
/
Subcutaneous Fat
/
Adiposity
/
Waist Circumference
/
Obesity, Abdominal
Limits:
Adult
/
Aged
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2013
Document type:
Article