Efficacy of Peginterferon and Ribavirin Combination Therapy of Chronic Hepatitis C: A Pooled Analysis / 대한소화기학회지
The Korean Journal of Gastroenterology
; : 306-314, 2012.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-11957
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
A combination of peginterferon and ribavirin is the standard therapy for chronic hepatitis C (CHC). However, the respective study has not been carried out in a large scale in Korea. The purpose of this study was to collect the studies that have been reported in Korea in order to analyze the therapeutic effect of combination therapy and compare to find racial difference.METHODS:
Twenty-eight papers related to the therapeutic effect of combination therapy in CHC patients were analyzed based on pooled analysis.RESULTS:
Based on the analysis for genotype 1 in Korea, early virologic response (EVR), end of treatment response (ETR), and sustained virologic response (SVR) were 79.6% (125/157), 80.1% (166/207), and 62.7% (341/543). The EVR, ETR, and SVR for genotype 2 and 3 were 89.4% (119/133), 92.2% (203/220), and 84.1% (434/516). Data from other Asians showed that EVR and SVR for genotype 1 were 88.9% (290/326) and 64.4% (491/762) respectively and 88.8% (135/152), and 79.4% (151/190) for genotype 2 and 3 respectively. In Western, EVR and SVR for genotype 1 were 51.3% (1,981/3,860) and 42.4% (1,798/4,231) respectively, and for genotype 2 and 3 were 87.7% (350/399) and 77.8% (533/685) respectively. Based on the comparative analysis, no statistical difference in SVR between Koreans and other Asians (p=0.955) was observed; However, the SVR of Koreans was higher with significance than that of Westerns (p<0.001) On the other hand, there was no difference what so ever, in SVR for genotype 2 amongst the different races.CONCLUSIONS:
The SVR of combination therapy for the Korean chronic hepatitis C patients was similar to other Asians but higher than Westerns.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.3: End transmission of communicable diseases
Database:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Polyethylene Glycols
/
Ribavirin
/
Recombinant Proteins
/
Databases, Factual
/
Treatment Outcome
/
Interferon-alpha
/
Hepacivirus
/
Hepatitis C, Chronic
/
Drug Therapy, Combination
Limits:
Humans
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2012
Document type:
Article