Significance of Non-erosive Minimal Esophageal Lesions in Gastro-esophageal Reflux Disorder
The Korean Journal of Internal Medicine
; : 93-98, 2004.
Article
in En
| WPRIM
| ID: wpr-122278
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Non-erosive reflux disorder, which represents more than 60% of gastro-esophageal reflux disorders, lacks objective parameters for diagnosis. The purpose of this study was to evaluate the correlation between non-erosive minimal lesions at the lower esophagus and gastro-esophageal reflux disorder. METHODS: Patients were asked to answer a symptom questionnaire. The endoscopic findings were either graded by LA classification or recorded as non-erosive minimal lesions. Patients with minimal lesions were treated with rabeprazole or a placebo and responses were evaluated at weeks 1 and 4. RESULTS: In 8 centers, 3454 patients were screened. In patients with heartburn or acid regurgitation as the most bothersome symptom, 23.7% had endoscopy negative reflux disorder, 40.1% showed minimal lesions, and 36.2% had mucosal break esophagitis. Thirty-four percent of patients with minimal lesions and 39.1% of patients with LA 'grade A' mild esophagitis reported typical reflux symptoms as their main symptom. In patients with minimal lesions, medication with rabeprazole reduced symptoms significantly at weeks 1 and 4, but not with the placebo. CONCLUSION: Patients with non-erosive minimal esophageal lesions had similar reflux symptoms comparable to those with mild erosive reflux esophagitis, and reflux symptoms were improved with a short-term proton pump inhibitor. Thus, non-erosive minimal esophageal lesion constitutes a great part of gastro-esophageal reflux disorder.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Benzimidazoles
/
Omeprazole
/
Gastroesophageal Reflux
/
Prospective Studies
/
Follow-Up Studies
/
Treatment Outcome
/
Proton-Translocating ATPases
/
Enzyme Inhibitors
/
Esophageal Diseases
/
2-Pyridinylmethylsulfinylbenzimidazoles
Type of study:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
The Korean Journal of Internal Medicine
Year:
2004
Document type:
Article