Effect of Ultra-marathon (308 km) Race on Bone Metabolism and Cartilage Damage Biomarkers
Annals of Rehabilitation Medicine
; : 80-87, 2012.
Article
in En
| WPRIM
| ID: wpr-122701
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: To evaluate the potential effects of a 308-km ultra-marathon on bone and cartilage biomarkers. METHOD: Venous blood samples were collected at pre-race, 100 km, 200 km, and 308 km checkpoints. The following markers of cartilage damage and bone metabolism were studied: osteocalcin (OC), osteoprotegerin (OPG), and calcium, phosphorous, and cartilage oligomeric matrix protein (COMP). RESULTS: Blood samples were taken from 20 male runners at four different checkpoints. Serum COMP was increased by 194.1% (130.7% at 100 km and 160.4% at 200 km). Serum OPG was significantly increased by 158.57% at 100 km and 114.1% at 200 km compared to the pre-race measures. OC was transiently suppressed at 200 km. Serum calcium and phosphorous concentrations decreased compared to the pre-race measures. CONCLUSION: This study showed that the 308-km ultra-marathon induced several changes, including transient uncoupling of bone metabolism, increased bone resorption, suppressed bone formation, and bone turnover and had a major impact on cartilage structure.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Osteogenesis
/
Bone Resorption
/
Glycoproteins
/
Biomarkers
/
Cartilage
/
Osteocalcin
/
Calcium
/
Extracellular Matrix Proteins
/
Racial Groups
/
Osteoprotegerin
Aspects:
Determinantes_sociais_saude
Limits:
Humans
/
Male
Language:
En
Journal:
Annals of Rehabilitation Medicine
Year:
2012
Document type:
Article